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pentobarbital will lower the extent or result of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Powerful or moderate CYP3A4 inducers may well enhance fee of diazepam elimination; hence, efficacy of diazepam can be lessened.pentobarbital improves effects of ifosfamide by influencing hepatic enzyme CYP2B6